It has been over a decade since TUI Airways flew out of the airport in Eastleigh, but it will now take passengers on its regular flights to Palma De Mallorca.
The first flight to the largest of the Balearic Islands left Tuesday at full capacity.
This weekly service will continue until the end of September, aligning with Marella Cruises’ summer programme.
The reintroduced route offers holidaymakers a convenient connection to Mallorca’s beaches, cultural attractions, and Mediterranean climate.
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Gavin Williams, managing director at Southampton Airport, said: “Our passengers were hugely excited when the return of TUI was first announced last year.
“It was fantastic to see our passengers on the first services which provides an exciting new travel opportunity for the Central South region.
“We look forward to welcoming more passengers on this flight as we continue to expand and enhance our travel options.”
TUI UK’s director of flight capacity management aviation planning, Karen Switzer, said: “We are extremely excited to see the return of TUI Airways to Southampton Airport to reconnect travellers with the vibrant corner of the world that is Palma.
“We understand how important it is for customers to have access to flights from their local airports, and this latest addition brings the number of regional airports that TUI Airways fly from to 24.
“We look forward to welcoming customers on board from May next year and taking them away on their dream Mallorcan holiday.”
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The reintroduction of this route marks a significant expansion of travel options for the Central South region.
Airline easyJet also launched a new flight route from Southampton Airport in April.
The new route to Paris is the airline’s eighth from Southampton Airport, which takes passengers to Paris Orly twice a week.
The year-round new service will operate twice per week on Mondays and Fridays, with easyJet planning up to 21 weekly departures from Southampton during peak summer 2025.