Nadine Newsome, was last seen on Bursledon Road, Hedge End, at around 7.30am on Monday.
She is described as white, around 5ft, with red/brown hair. She was last seen wearing an olive green coat, blue jeans, pink socks, and black trainers.
Police say Nadine could have got on a bus to Eastleigh or Southampton.
A police spokesperson said: “We’re concerned for Nadine’s welfare and would ask anyone who thinks they’ve seen her today or anyone who thinks they might know where she is now, to call us immediately on 999 quoting 44250251378.”