Protestors gathered outside the Highfield House Hotel, in Highfield Lane for a “peaceful” protest, with officers from Hampshire Constabulary at the scene to maintain public safety.
The hotel houses asylum seekers and refugees.
Following the protest, Southampton Test MP Satvir Kaur said that while everyone has the right to a peaceful protest, hate is not welcome in the city.
Speaking to the Echo, she said: “Southampton has been welcoming people from around the world for centuries, it has made us who we are, vibrant, diverse, multi-skilled, resourceful, innovative and so much more.
“Of course everyone has a right to protest peacefully, but hate and racism never has or ever will, be welcome in our great and proud city of sanctuary.”
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Cllr John Savage, who represents Portswood, said the news of the protest was “really concerning.”
He added: “There is no place for it in Southampton.
“Instead people should write to their MPs or turn up at the council chambers, rather than bothering people in the hotel, some of which would have been there a long time and are waiting to be housed.
“If people are there in force it can be quite frightening for people nearby.
“People can protest peacefully but Southampton is a city of sanctuary.
“I have spoken to people who have concerns about immigration but they’re also very sympathetic to the situation.”
In a statement, a spokesperson for Hampshire Constabulary said, “the protest was peaceful and passed without any incidents reported to police during the event.”
The force spokesperson added: “Our priority with protests is always public safety.
“Policing these events requires us to balance the rights of those lawfully protesting, and the rights of others to go about their lives without being subject to unacceptable disruption, whilst keeping the public safe.”